Pharmacologic treatments for covid-19 patients

Inhaled corticosteroids vs Standard care/Placebo


Outpatients

Forest plots
(last update: 2022-10-07)

Summary of findings
(last update: 2022-10-14)

Hospitalized patients

Forest plots
(last update: 2022-10-07)

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Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
NCT04885530
ACTIV 6
Naggie S, medRxiv, 2022
Full text
Commentary
Commentary
Mixed

Fluticasone (inhaled)

Placebo

RCT Outpatients with confirmed COVID-19 (mild) treated at 93 centers in the USA. N=1407
Some concerns
Details

Full description

NCT04356495, EudraCT 2020-001435-27
COVERAGE
Duvignaud A, Clin Microbiol Infect, 2022
Full text
Commentary
Public/non profit

Ciclesonide

Standard care

RCT Outpatients with confirmed COVID-19 (symptomatic) treated by 14 centers in France N=217
Some concerns
Details

Full description

N/A
Alsultan M, Interdiscip Perspect Infect Dis, 2021
Full text
Commentary
Not reported/unclear

Colchicine

Budesonide

Colchicine

Standard care

Standard care

Budesonide

RCT Patients with suspected or confirmed COVID-19 (moderate-severe) admitted to a single center in Syria. N=49 N/A

Full description

NCT04435795
CONTAIN
Ezer N, BMJ, 2021
Full text
Commentary
Commentary
Mixed

Ciclesonide

Placebo

RCT Outpatients with confirmed COVID-19 (mild, symptomatic) treated by multiple centers in Canada N=215
Some concerns
Details

Full description

NCT04377711
Clemency B, JAMA Intern Med, 2021
Full text
Full text
Commentary
Private

Ciclesonide

Standard Care

RCT Outpatients with confirmed COVID-19 (mild, symptomatic) treated by 10 centers in the USA. N=400
Some concerns
Details

Full description

NCT04330586
Song JY, J Clin Med, 2021
Full text
Commentary
Mixed

Ciclesonide

Standard care

RCT Patients with confirmed COVID-19 (mild-moderate) admitted to 6 centers in South Korea. N=61
High
Details

Full description

ISRCTN86534580; EudraCT 2020-001209-22
PRINCIPLE
Yu LM, Lancet, 2021
Full text
Full text
Commentary
Commentary
Commentary
Public/non profit

Budesonide

Standard care

RCT Outpatients with suspected or confirmed COVID-19 (symptomatic-mild) treated by multiple centers in the UK N=1073
Some concerns
Details

Full description

NCT04416399
STOIC
Ramakrishnan S, Lancet Respir Med, 2021
Full text
Commentary
Commentary
Mixed

Budesonide

Standard care

RCT Outpatients with suspected or confirmed COVID-19 (mild) treated by a single center in the UK N=146 N/A

Full description