Vitamin D vs Standard care/Placebo (RCT)

Summary of findings
(last update: 2021-10-04)

Patient or population: COVID-19 patients
Setting: Worldwide
Intervention: Vitamin D
Comparison: Standard care/Placebo

Outcome Relative effect
(95% CI)
Absolute effect
(95% CI)1
Certainty of the Evidence
(GRADE)
Viral negative conversion
D7
Outcome not yet measured or reported
Clinical improvement
D28
RR: 1.12
(0.01 - 1.24)
106 more per 1000
(from 874 fewer to 212 more)

Low certainty

Reasons to downgrade

2 trials
126 participants
Vitamin D
988 per 1,000
(9 - 1000)
Standard care/Placebo
882
per 1,000
Clinical improvement
D60
Outcome not yet measured or reported
WHO progression score (level 7 or above)
D28
RR: 0.04
(0.01 - 0.29)
480 fewer per 1000
(from 495 fewer to 355 fewer)

Very low certainty

Reasons to downgrade

1 trials
76 participants
Vitamin D
20 per 1,000
(5 - 145)
Standard care/Placebo
500
per 1,000
WHO progression score (level 7 or above)
D60
Outcome not yet measured or reported
All-cause mortality
D28
RR: 0.44
(0.07 - 2.97)
36 fewer per 1000
(from 60 fewer to 127 more)

Very low certainty

Reasons to downgrade

3 trials
366 participants
Vitamin D
28 per 1,000
(5 - 191)
Standard care/Placebo
64
per 1,000
All-cause mortality
D60
Outcome not yet measured or reported
Adverse events
RR: 3.00
(0.12 - 72.91)
Absolute effects were not calculated due to zero events in the control group
Low certainty

Reasons to downgrade

1 trials
240 participants
Vitamin D
0 per 1,000
(1 - 608)
Standard care/Placebo
0
per 1,000

1 additional study was identified that assessed this outcome, but no results were reported.

Serious adverse events
Outcome not yet measured or reported
Hospitalisation or death
*
RR:
( - )
Zero events in both groups0 per 1000
(from 0 to 0 )


Reasons to downgrade

trials
0 participants
Vitamin D
0 per 1,000
( - )
Standard care/Placebo
0
per 1,000

1The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI)

CI: Confidence interval; RR: Risk ratio

GRADE Working Group grades of evidence
High certainty: We are very confident that the true effect lies close to that of the estimate of the effect
Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect
Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect

Studies description

Study : NCT04366908 (Entrenas Castillo M, J Steroid Biochem Mo, 2020, Full text)

Rob

Study : NCT04459247 (Rastogi A, Postgrad Med J, 2020, Full text)

Rob

Study : NCT04449718 (Murai IH, Jama, 2021, Full text)

Rob

Study : * (Elamir YM, Bone, 2021, Full text)

Rob