Covid-19 Living Data

Trial *
Publication Wu J, medRxiv, 2020
Dates: 26dec2019 to 15mar2020

Methods
	Non-randomized study
	Location : Multicenter / China Follow-up duration (days): 28
Inclusion criteria	Consecutive inpatients with laboratory confirmed or clinically diagnosed COVID-19 from Wuhan Hankou Hospital and No. Six Hospital of Wuhan between December 26th, 2019 and March 15th 2020 were collected in this study. Critical cases were those who met any of the following conditions during the whole hospital stay: 1. mechanical ventilation was required; 2. required treatment in intensive care unit (ICU); 3. shock occurred in hospital
Exclusion criteria	Patients who met any of the following conditions were exclude from the study: 1. Non severe or critical cases; 2. Not being diagnosed as severe cases within 24 hours since admission; 3. The time of being diagnosed of severe/critical cases were missing.
Type of analysis	Propensity score matching
Interventions

	Treatment 1 Corticosteroids (HC, MPS, DM) 6 days Definition of Standard care: *
	Treatment 2 Corticosteroids (HC, MPS, DM) 5 days Definition of Standard care: *
Participants
	N analyzed 720 participants (n₁=360 / n₂= 360)
	Characteristics of participants N=720 Mean age : NR 369 males Severity : Mild: n=0 / Moderate: n=/ Severe: n= Critical: n=*
Primary outcome
	In the register NR
	In the report Time to in-hospital death
Documents avalaible	Protocol NR Statistical plan NR Data-sharing stated Yes
Risk of bias Overall The overall risk of bias reported in the table corresponds to the highest risk of bias for the outcomes assessed for the systematic review	Serious
Notes	This is an emulated trial. No registration or protocol were available. The study compares use of any intravenous corticosteroid in hospital, against no corticosteroid use. Patients in both arms were cared for in two hospitals in Wuhan, China We therefore extracted 'standard care' as present in both arms. We extracted propensity score matched baseline data (Appendix tables 3 and 6) and outcomes. The analyses were performed separately for patients classified as critical or severe (severe illness was defined by the authors as patients requiring oxygen).