Trial N/A
Publication Rajter J, medRxiv, 2020
Dates: 3/15/2020 to 5/11/2020
| Methods | |
| Non-randomized study | |
| Location :
Multicenter / USA Follow-up duration (days): * | |
| Inclusion criteria | Sequentially consecutive hospitalized patients at four Broward Health associated hospitals in South Florida with laboratory-confirmed infection with SARS-CoV-2 during their admission |
| Exclusion criteria | Patients younger than 18 years old, pregnant, or incarcerated wereexcluded from the data collection based on IRB requirements.Patients who had at least2 separate admissions placing them in both groups were also excluded. |
| Type of analysis | Propensity score stratification |
| Interventions | |
| Treatment
Ivermectin (200 mcg/kg) Co-Intervention: Standard care |
|
| Control
Standard care Definition of Standard care: The decision to prescribe ivermectin, hydroxychloroquine, azithromycin or other medications was at the discretion of the treating physicians, however hospital guidelines were established for the use of these agents as well as for cardiac and QT monitoring for patients receiving hydroxychloroquine. Oxygen and ventilatory support were applied per the customary care | |
| Participants | |
| N analyzed 280 participants (n1=173 / n2= 107) | |
| Characteristics of participants N=280 Mean age : 59,6 153 males Severity : Mild: n=0 / Moderate: n=205/ Severe: n=75 Critical: n=0 | |
| Primary outcome | |
| In the register NR | |
| In the report all-cause in-hospital mortality | |
| Documents avalaible |
Protocol No Statistical plan No Data-sharing stated Yes |
| Risk of bias Overall The overall risk of bias reported in the table corresponds to the highest risk of bias for the outcomes assessed for the systematic review |
Serious |
| Notes | This is a quasi-experimental study. The baseline data are extracted from Table 1 with some imbalances on certain confounders.C They concern the unadjusted sample (n=280). The time to death HR is adjusted using multivariate analysis. Some potential confounders are unbalanced at baseline but were not controlled for like ethnicity ad immunosuppression. No registration or protocol were available. |