Trial N/A
Publication Yu B, Sci China Life Sci, 2020
Dates: 2/1/2020 to 4/4/2020
| Methods | |
| Non-randomized study | |
| Location :
single / China Follow-up duration (days): 60 | |
| Inclusion criteria | The inclusion as critically ill patients had to meet one of the following criteria: (i) patients had respiratory failure and needed mechanical ventilation; (ii) patients had septic shock during hospitalization; (iii) patients with other organ failures that required monitoring and treatment by intensive care unit. In this study, we included all critically ill adult patients (age>18 years old) with hospitalization during the epidemic period from February 1, 2020 to April 4, 2020. |
| Exclusion criteria | NR |
| Type of analysis | Multivariable Cox regression |
| Interventions | |
| Treatment
Hydroxychloroquine (200 mg) Co-Intervention: Standard care Duration : 7-10 days |
|
| Control
Standard care Definition of Standard care: basic treatments including antiviral drugs and antibiotics | |
| Participants | |
| N analyzed 550 participants (n1=48 / n2= 502) | |
| Characteristics of participants N=550 Mean age : NR 344 males Severity : Mild: n=0 / Moderate: n=0/ Severe: n=0 Critical: n=550 / Critical= 550 | |
| Primary outcome | |
| In the register NR | |
| In the report mortality | |
| Documents avalaible |
Protocol NR Statistical plan NR Data-sharing stated Yes |
| Risk of bias Overall The overall risk of bias reported in the table corresponds to the highest risk of bias for the outcomes assessed for the systematic review |
Serious |
| Notes | This is a quasi-experimental study. The baseline data are extracted from Table 1 with some imbalances on certain confounders. They concern the unadjusted sample (n=550). The time to death HR is adjusted using multivariate cox regression analysis. No registration or protocol were available. |